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牛结核病疫苗研究进展

点击数:18706  时间:2019-05-10 13:32:38  来源: 中国动物检疫      作者: 张喜悦

目前处于临床试验阶段的医用结核病疫苗共计15种,其中临床I期6种、Ⅱ期6种、Ⅱb期2种、Ⅲ期1种。医用疫苗的进步为牛结核病疫苗应用提供了更多的选择。20世纪90年代起,英国、新西兰、西班牙等国陆续开展了野生动物的牛结核病免疫田间试验。现在全球虽然仍禁止使用疫苗免疫牛,但很多学者仍然进行了大量的牛结核病疫苗研究。英国动植物健康署(APHA)通过试验证实,卡介苗(BCG)-病毒载体疫苗联合免疫可强化BCG免疫效果。欧盟开展了结核病阶梯项目(TBSTEP),研究根除牛结核病的策略,其中包括疫苗和诊断试剂研发。此外,为扩大试验范围,欧盟食品安全局还要求开展牛结核病疫苗田间试验。



Research Progress on Bovine Tuberculosis Vaccines

Presently,a total of15 kinds of medical tuberculosis vaccines are at the stage of clinical trials,including 6 kinds of vaccines at clinical stage I,6 kinds at stage II,2 kinds at stage II b,and 1 kind at stage III. With the development of medical vaccines,the bovine tuberculosis vaccines would be applied in a large range.Since the 1990s,the field trials for immunizationagainst bovine tuberculosis in wild animals have been carried out in the UnitedKingdom,New Zealand,Spain andother countries. Although it is still prohibited to use vaccines in cattle inthe world,a large number of related vaccine researcheswere carried out by many scholars. The immune effects of bacilluscalmette-guerin(BCG)could bestrengthened by combined immunization of BCG-viral vector vaccine as tested andconfirmed by British Animal and Plant Health Administration(APHA). The Tuberculosis Staging Project(TBSTEP)was performed by European Union tostudy strategies for eradicating bovine tuberculosis,includingthe development of vaccines and diagnostic reagents. In addition,the field trials for bovine tuberculosis vaccines were also requiredto carry out by European Union Food Safety Authority so as to enlarge the scopeof trials.




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